Spider-Man Vol 1 #17

After a chemical accident, Spider-Man’s consciousness is separated from his body and he enters an alternate plane where Death herself lies in wait! Not to mention Thanos is there too, in possession of the Infinity Gauntlet!

In this issue Spider-Man dies!

That's no joke.

Attempting to save the life of a little girl the wall-crawler is killed.

Now, in an ominous journey through the afterworld, Spider-Man comes face-to-face with the Mad Titan himself, Thanos, and his dark mistress, Death!

Is this truly the end of everyone's favorite friendly neighborhood Spider-Man?